RPI-BLB2-MEDIATED HYPERSENSITIVE CELL DEATH CAUSED BY PHYTOPHTHORA INFESTANS AVRBLB2 REQUIRES SGT1, BUT NOT EDS1, NDR1, SALICYLIC ACID-, JASMONIC ACID-, OR ETHYLENE-MEDIATED SIGNALING

Rpi-blb2-Mediated Hypersensitive Cell Death Caused by Phytophthora infestans AVRblb2 Requires SGT1, but not EDS1, NDR1, Salicylic Acid-, Jasmonic Acid-, or Ethylene-Mediated Signaling

Potato Rpi-blb2 encodes a protein with a coiled-coil-nucleotide binding site and leucine-rich repeat (CC-NBS-LRR) motif that recognizes the Phytophthora infestans AVRblb2 effector and triggers hypersensitive cell death (HCD).To better understand the components required for Rpi-blb2-mediated HCD in plants, we used virus-induced gene silencing to rep

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Activation of RIG-I-Mediated Antiviral Signaling Triggers Autophagy Through the MAVS-TRAF6-Beclin-1 Signaling Axis

Autophagy has been implicated in innate immune responses against various intracellular pathogens.Recent studies have reported that autophagy can be triggered by pathogen recognizing sensors, including Toll-like receptors and cyclic guanosine monophosphate-adenosine monophosphate synthase, to participate in innate immunity.In the present study, we e

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The efficacy of Narrative Exposure Therapy for Children (KIDNET) as a treatment for traumatized young refugees versus treatment as usual: update to the study protocol for the multi-center randomized controlled trial YOURTREAT

Abstract Background The trial YOURTREAT aims to compare the pragmatic, short-term psychotherapy Narrative Exposure Therapy for Children (KIDNET) with treatment as usual (TAU) for Hooks the treatment of young refugees in Germany.This update outlines changes made to the study protocol in response to the current COVID-19 pandemic with the aim of allow

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